Duke Center for Human Genetics Duke University Medical CenterDuke University

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Mission

Faculty

Allison Ashley-Koch, PhD

Simon G. Gregory, PhD

Elizabeth R. Hauser, PhD

Michael A. Hauser, PhD

Yi-Ju Li, PhD

Yutao Liu, PhD

Svati H. Shah, MD, MHS

Michelle P. Winn, MD

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Core Faculty

Elizabeth R. Hauser, PhDElizabeth R. Hauser, PhD, is a Professor in the Section of Medical Genetics, Department of Medicine. Dr. Hauser is a statistical geneticist with experience in the development and application of methods for the analysis of affected sibling pair data in studies of complex genetic disorders. Her current research interests include cardiovascular genetics, informatics, and methodologic developments for complex diseases.

Dr. Hauser is affiliated with the Computational Biology and Bioinformatics program..

Hauser
MHS, 1985, Epidemiology/Genetic Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health
MS, 1992, Biostatistics, University of Michigan, Ann Arbor, MI
PhD, 1998, Biostatistics, University of Michigan, Ann Arbor, MI


Selected Publications

Qin X, Hauser ER, Schmidt S. Ordered subset analysis for case-control studies. In press, Genetic Epidemiology.

Shah SH, Bain JR, Muehlbauer MJ, Stevens RD, Crosslin DR, Haynes C, Dungan J, Newby LK, Hauser ER, Ginsburg GS, Newgard CB, Kraus WE. Association of a Peripheral Blood Metabolic Profile with Coronary Artery Disease and Risk of Subsequent Cardiovascular Events. Circ Cardiovasc Genet. 2010;3:207-214

Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, Johnson J, Nelson S, Wang L, Connelly JJ, Muehlbauer M, Ginsburg GS, Crossman DC, Jones CJ, Vance J, Sketch MH, Granger CB, Newgard CB, Gregory SG, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER. Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis. PLoS Genet. 2009 Jan;5(1):e1000318.doi:10.1371/journal.pgen.1000318.

Crosslin DR, Shah SH, Nelson SC, Haynes CS, Connelly JJ, Gadson S, Goldschmidt-Clermont PJ, Vance JM, Rose J, Granger CB, Seo D, Gregory SG, Kraus WE, Hauser ER. Genetic Effects in the Leukotriene Biosynthesis Pathway and Association with Atherosclerosis. Hum Genet. 2009 Mar;125(2):217-29.

Shah SH, Hauser ER, Bain JR, Muehlbauer MJ, Stevens RD, Wenner BR, Haynes C, Dowdy ZE, Granger CB, Ginsburg GS, Newgard CB, Kraus WE. High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. Mol Syst Biol. 2009;5:258. Epub 2009 Apr 7.

Wang T, Furey, TS, Connelly JJ, Ji S, Nelson S, Heber S, Gregory SG, Hauser ER. A general integrative genomic feature transcription factor binding site prediction method applied to analysis of USF1 binding in cardiovascular disease Human Genomics 2009 3(3): 221-235.

Schmidt S, Schmidt MA, Qin X, Martin ER, Hauser ER. Increased efficiency of case-control association analysis by using allele-sharing and covariate information. Human Heredity, 2008;65(3):154-65.

Sutton BS, Crosslin DR, Shah SH, Nelson SC, Bassil A, Hale AB, Haynes C, Goldschmidt-Clermont, PJ, Vance JM, Kraus WE, Gregory SG, Hauser ER. Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case/control and family datasets. Human Molecular Genetics 2008, 17(9):1318-1328.

Connelly JJ, Shah SH, Doss JF, Gadson S, Nelson S, Crosslin DR, Hale AB, Lou X, Wang T, Haynes C, Seo D, Crossman DC, Mooser V, Granger CB, Jones CJH, Kraus WE, Hauser ER, Gregory SG. Genetic and functional association of FAM5C with myocardial infarction. BMC Medical Genetics 2008, 9:33 (22 Apr 2008).

Chung RH, Schmidt S, Martin ER, Hauser ER. Ordered-subset analysis (OSA) for family-based association mapping of complex traits. Genet Epidemiol. 32(7):627-37, 2008.

Chung, RH; Hauser, ER; Martin, ER. Interpretation of simultaneous linkage and family-based association tests in genome screens. Genet Epidemiol. 31(2):134-42, 2007.

Murtha AP, Sinclair T, Hauser ER, Swamy GK, Herbert WN, Heine RP. Maternal serum cytokines predict infection in preterm premature rupture of membranes. Obstet Gynecol. Jan;109(1):121-7, 2007.

Wang L, Hauser ER, Shah SH, Pericak-Vance MA, Haynes C, Crosslin D, Harris M, Nelson S, Hale AB, Granger CB, Haines JL, Jones CJ, Crossman D, Seo D, Gregory SG, Kraus WE, Goldschmidt-Clermont PJ, Vance JM. Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease. Am J Hum Genet. 2007 Apr;80(4):650-63.

Schmidt S, Qin X, Schmidt MA, Martin ER, Hauser ER. Interpreting analyses of continuous covariates in affected sibling pair linkage studies. Genet Epidemiol 2007 Sep;31(6):541-52.

Dube M-P, Schmidt S, Hauser ER. Multistage designs in the genomic era: Providing balance in complex disease studies. Genetic Epidemiol 2007;31 Suppl 1:S118-23.

Schmidt S, Schmidt MA, Qin X, Martin ER, Hauser ER. Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis. Genet Epidemiol 2006 Jul;30(5):409-22.

Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC, Granger CB, Haines JL, Jones CJH, Vance JM, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER, Gregory SG. GATA2 is associated with familial early onset coronary artery disease. PLoS Genet 2(8): e139. doi:10.1371/journal.pgen.0020139.

Murtha AP, Nieves A, Hauser ER, Swamy GK, Yonish BA, Sinclair TR, Heine RP. Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth. 2006 Am J Obstet Gynecol. Nov;195(5):1249-53.

Xu H, Hauser ER, Hauser MA, Zuchner S, Gregory SG, Stenger JE, Pericak-Vance MA, Vance JM. SNPselector: A web tool for selecting SNPs for genetic association studies. Bioinformatics 2005 Nov 15;21(22):4181-6 [Epub Sep 22] 2005

Schmidt M, Hauser ER, Martin ER, Schmidt SA. Extension of the SIMLA package for generating pedigrees with complex inheritance patterns: environmental covariates, gene-gene and gene-environment interaction. Statistical Applications in Genetics and Molecular Biology:4(1): Article 15, 2005.

Contact at:
Center for Human Genetics
DUMC Box 3445
Durham, NC 27710
Phone: 1-919-684-0603
Fax: 1-919-684-0913
E-mail: Elizabeth.Hauser@duke.edu

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