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Faculty

Allison Ashley-Koch, PhD

Simon G. Gregory, PhD

Elizabeth R. Hauser, PhD

Michael A. Hauser, PhD

Yi-Ju Li, PhD

Yutao Liu, PhD

Svati H. Shah, MD, MHS

Michelle P. Winn, MD

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Core Faculty

Michelle P. Winn, MDMichelle P. Winn, MD, is an Associate Professor in the Division of Nephrology, Department of Medicine. Dr. Winn is a board certified nephrologist. Her research interests include the hereditary diseases of the human kidney. She is currently focusing her research on familial focal segmental glomerulosclerosis. Her other interests include complex diseases in relation to kidney function such as hypertensive nephropathy, end-stage renal disease and acute renal failure.

MD, 1992, East Carolina University-School of Medicine, Greenville, NC
Residency in Internal Medicine, Duke University Medical School, Durham, NC
Fellowship in Nephrology, Duke University Medical Center, Durham, NC

Selected Publications

Winn MP, Bollinger RR, Conlon PJ. Orthostatic acute renal failure in a renal transplant. Transplant International, 10(5):395-7, 1997.

Winn MP, McDermott VG, Schwab SJ, Conlon PJ. Dialysis catheter 'fibrin-sheath stripping': a cautionary tale. Nephrology, Dialysis and Transplantation, 12(5):1048-50, 1997.

Winn MP, Conlon PJ, Lynn KL, Howell DN, Gross DA, Rogala AR, Smith AH, Graham FL, Bembe M, Quarles LD, Pericak-Vance MA, Vance JM. Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis. Kidney International 55(4):1241-6, 1999.

Winn MP, Al Khunaizi AM, Bennett WM, Howell DN, Garber RL, Butterly DW, Conlon PJ. Focal and segmental glomerulosclerosis: a need for caution in live-related renal transplantation. American Journal of Kidney Disease, 33(5):970-974, 1999.

Conlon PJ, Lynn K, Winn MP, Quarles LD, Bembe ML, Pericak-Vance M, Speer M, Howell DN. Spectrum of disease in familial focal and segmental glomerulosclerosis. Kidney International 56(5):1863-71, 1999.

Winn MP, Conlon PJ, Lynn KL, Howell DN, Slotterbeck BD, Smith AH, Graham FL, Bembe M, Quarles LD, Pericak-Vance MA, Vance JM. Linkage of a gene causing familial focal segmental glomerulosclerosis to chromosome 11 and further evidence of genetic heterogeneity. Genomics 58(2):113-20, 1999.

Conlon PJ, Stafford-Smith M, White WD, Newman MF, King S, Winn MP, Landolfo K. Acute renal failure following cardiac surgery. Nephrology Dialysis Transplantation, 14:1158-1162, 1999.

Hsu SI, Ramirez SB, Winn MP, Bonventre JV, Owen WF. Evidence for Genetic Factors in the Development and Progression of IgA Nephropathy. Kidney International, 57:1818-1835, 2000.

Neary JJ, Conlon PJ, Croke D, Dorman A, Keoghan M, Zhang FY, Vance JM, Pericak-Vance MA, Scott WK, Winn MP. Linkage of a Gene Causing Familial Membranoproliferative Glomerulonephritis Type III to Chromosome 1. J Am Soc Nephrol 13: 2052-2057, 2002.

Oliveira SA, Scott WK, Martin ER, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Scott BL, Goetz CG, Small GW, Mastaglia F, Stajich JM, Zhang F, Booze MC, Winn MP, Middleton LT, Haines JL, Pericak-Vance MA, Vance JM. Parkin Mutations and Susceptibility Alleles in Late-Onset Parkinson's Disease. Ann Neurol May 2003; 53:624-629

Winn MP. Approach to the evaluation of heritable diseases and update on familial focal segmental glomerulosclerosis. Nephrology Dialysis Transplantation. 18 [Suppl 6]: vi14-vi20, 2003

Stafford-Smith M, Podgoreanu M, Swaminathan M, Phillips-Bute B, Mathew JP, Hauser EH, Winn MP, Milano C, Nielson DM, Smith M, Morris R, Newman MF, Schwinn DA. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. American Journal of Kidney Disease, Vol 45, No. 3 (March ) 2005; pp. 519-530.

Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB. A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis. Science 5 May 2005; 308:1801-4.

Winn, MP, Daskalakis N, Spurney RF, Middleton, JP. Unexpected Role of TRPC6 Channel in Familial Nephrotic Syndrome: Does it Have Clinical Implications? Journal of the American Society of Neprology, 2006 Feb;17(2):378-87.

Daskalakis N and Winn MP. Human genome and diseases: Glomerulosclerosis. Cellular and Molecular Life Sciences, Cell Mol Life Sci. 2006 Sep 4 .

Mukerji N, Damadoran, TV and Winn MP. TRPC6 and FSGS: The Latest TRP Channelopathy. Biochemica et Biophysica Acta; Molecular Basis of Disease, Special Issue The Role of TRP Channels in Disease, 2007; 1772: 859-868.

Winn MP. 2007 Young Investigator Award: TRP'ing into a New Era for Glomerular Disease. J Am Soc Nephrol, 2008 Jun;19(6):1071-5.

Lavin P, Gbadegesin R, Damodaran TV, Winn, MP. Therapeutic targets in FSGS. Curr Opin Nephrol and Hyperten, 2008 Jul; 17(4):386-392.

Gbadegesin R, Bartkowiak B, Lavin PJ, Mukerji N, Wu G, Bowling B, Eckel J, Damodaran T, Winn MP. Exclusion of homozygous PLCE1 (NPHS3) mutations in 69 families with idiopathic and hereditary FSGS. Pediatr Nephrol. 2009 Feb; 24(2):281-5.

Seth M, Zhang Z, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn, MP, Abramowitz J, Rockman, HA, Birbaumer L, Rosenberg P. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Research. 2009 Nov 6;105(10):1023-30.

Gbadegesin R, Lavin P, Janssens L, Bartkowiak B, Homstad A, Wu G, Bowling B, Eckel J, Potocky C, Abbott D , Conlon P, Scott WK, Howell D, Hauser E, Winn MP. A New Locus for Familial FSGS on Chromosome 2p. J Am Soc Nephrol. 2010 Aug;21(8):1390-7.

Svetkey LP, Harris E, Martin E, Vollmer WM , Meltesen GT, Ricchiuti V, Williams G, Appel LJ, Bray G, Moore T, Winn MP, Conlin PR. Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. Am J Hypertension. 2010 Nov 18;24(2):209-217.

Eckel J, Lavin PJ, Finch EA, Mukerji N, Burch J, Gbadegesin R, Wu G, Bowling, B, Byrd A, Hall G, Sparks M, Zhang ZS, Homstad A, Barisoni L, Birnbaumer L, Rosenberg P, Winn MP. TRPC6 enhances angiotensin II-induced albuminuria. J Am Soc Nephrol. 2011 Mar;22(3):526-35.

Jungraithmayr TC, Hofer K, Cochat P, Chernin G, Cortina G, Fargue S, Grimm P, Knueppel T, Kowarsch A, Neuhaus T, Pagel P, Pfeiffer KP, Schafer F, Schonermarck U, Seeman T, Burkhard T, Weber S, Winn MP, Zschocke J and Zimmerhackl LB. Screening for NPHS2 mutations may help predict recurrence after transplantation. J Am Soc Nephrol, 2011 Mar;22(3):579-85.

Gbadegesin R, Lavin P, Foreman J, Winn MP. Pathogenesis and therapy of focal segmental glomerulosclerosis: an update. Pediatr Nephrol. 2011 Jul;26(7):1001-15. Epub 2010 Nov 26. Review.

Luo X, Hall G, Li S, Bird A, Lavin PJ, Winn MP, Kemper A, Brown T, Koeberl DD. Hepatorenal correction in murin glycogen storage disease type 1 with a double-stranded adeno-associated virus vector. Mol Ther, 2011 Nov;19(11):1961-70.

Gbadegesin RA, Lavin PJ, Hall G, Bartkowiak B, Homstad A, Jiang R, Wu G, Byrd A, Lynn K, Wolfish N, Ottati C, Stevens P, Howell D, Conlon P, Winn MP. Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis. Kidney Int, 2012 Jan;81(1):94-9. Epub 2011 Aug 24.

Akilesh S, Suleiman H, Yu H, Stander MC, Lavin P, Antignac C, Pollak M, Winn MP, Shaw AS. Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. J Clin Inves, 2011 Oct;121(10):4127-37. Epub 2011 Sep 12.

Malik TH, Lavin PJ, Goicoechea de Jorge E, Vernon KA, Rose KL, Patel MP, de Leeuw M, Neary JJ, Conlon PJ, Winn MP, Pickering MC. A Hybrid CFHR3-1 Gene Causes Familial C3 Glomerulopathy. J Am Soc Nephrol, 2012 May 24. [Epub ahead of print]

Contact:
Center for Human Genetics
DUMC Box 2903
Durham, NC 27710
Phone: 1-919-660-0038
Fax: 1-919-684-0920
E-mail: michelle.winn@duke.edu

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