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Simon G. Gregory, PhD, is an Associate Professor in the Section of Medical Genetics, Department of Medicine. Dr. Gregory's role in the Duke CHG is to apply the experience gained from leading the mapping of the mouse genome and sequencing human chromosome 1 to elucidating the molecular mechanisms underlying multi-factorial diseases. His primary area of research involves the identific ation of the complex genetic factors that give rise to the development of cardiovascular disease and the detection of genes involved in multiple sclerosis. Dr. Gregory's group is also pioneering the application of high-resolution genomic microarrays for the discovery of chromosomal abnormalities and identification of epigenetic factors associated with human diseases such as cancer and autism. This project aims to correlate copy number profiles and factors such as methylation, with clinical phenotypes and differential levels of gene expression. His areas of special expertise are genome mapping, positional cloning and determining the effect that sequence variation has upon the etiology of genetic disease. Dr. Gregory is also director of the Duke Bioinformatics Workshop, a forum for researchers to gain in-depth experience of using publicly available molecular genomics databases.
Dr. Gregory is member of the graduate faculty of the Computational Biology and Bioinformatics, Molecular Genetics and Microbiology and University Program in Genetics and Genomics programs.
PhD, 2003, Wellcome Trust Sanger Institute, United Kingdom
The International Human Genome Sequencing Consortium.
Initial sequencing and analysis of the human genome.
Nature 409:860-921, 2001.
Gregory SG, Sekhon M, Schein J, Zhao S, Osoegawa K et al.
A physical map of the mouse genome.
Nature 418:743-50, 2002.
Mouse Genome Sequencing Consortium.
Initial sequencing and comparative analysis of the mouse genome.
Nature 420:520-562, 2002.
International Human Genome Sequencing Consortium.
Finishing the euchromatic sequence of the human genome.
Nature 431: 931–945, 2004.
Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, Sims J, Prokop AM, van der Walt J, DeLoa C, Lincoln RR, Oksenberg JR, Compston A, Hauser SL, Haines JL, Gregory SG.
Allelic Association of Sequence Variants in the Herpes Virus Entry Mediator-B Gene (PVRL2) with the Severity of Multiple Sclerosis.
Genes and Immunity (2006) 7, 384-92.
Gregory, SG, Barlow KF, McLay KE, Kaul R, et. al.
The DNA Sequence and Analysis of Chromosome 1.
Nature 441: 315-21,2006.
Connelly JJ, Wang T, Cox JE, Haynes C, Wang L, Shah SH, Crosslin DR, Hale AB, Nelson S, Crossman DC, Granger CB, Haines JL, Jones CJH, Vance JM, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER, Gregory SG.
GATA2 is associated with familial early onset coronary artery disease.
PLoS Genetics Vol. 2, No. 8.
Gregory SG, Schmidt S, Seth P, Oksenberg JR et al.
Interleukin 7 receptor a chain (IL7R) shows allelic and functional association
with multiple sclerosis. Nat Genet. 2007, 39(9):1083-91
The International Multiple Sclerosis Genetics Consortium.
Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study.
NEJM 2007 357:851-862 .
J.J. Connelly, S.H. Shah, J.F. Doss, S. Gadson, S. Nelson, D.R. Crosslin, A.B. Hale, X. Lou, T. Wang, C. Haynes, D. Seo, D.C. Crossman, V. Mooser, C.B. Granger, C.J.H. Jones, W.E. Kraus, E.R. Hauser and S.G. Gregory.
Genetic and functional association of FAM5C with myocardial infarction..
BMC Medical Genetics 2008, 9:33 (22 Apr 2008).
Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA, Lintas C, Abramson RK, Wright HH, Ellis P, Langford CF, Worley G, Delong GR, Murphy SK, Cuccaro ML, Persico A, Pericak-Vance MA.
Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.
BMC Med 2009 Oct 22;7:62.
Contact at:
Center for Human Genetics
DUMC Box 3445
Durham, NC 27710
Phone: 1-919-684-0726
Fax: 1-919-684-0924
E-mail: simon.gregory@duke.edu
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