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Allison Ashley-Koch, PhD

Simon G. Gregory, PhD

Elizabeth R. Hauser, PhD

Michael A. Hauser, PhD

Yi-Ju Li, PhD

Yutao Liu, PhD

Svati H. Shah, MD, MHS

Michelle P. Winn, MD

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Core Faculty

Yutao Liu, PhD Yutao Liu, PhD, is an Assistant Professor in the Section of Medical Genetics, Department of Medicine. He received his Ph.D. in molecular genetics from the graduate school of Genome Science & Technology (GST) at the University of Tennessee, Knoxville - Oak Ridge National Laboratory in 2006. Dr. Liu has been professionally trained in human genetics and functional genomics. His research interest is to identify genetic risk factors related to complex human diseases, such as primary open-angle glaucoma (POAG) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease). Dr. Liu is also interested in the role of genomic structural variation in human disease. As a postdoctoral associate at the Duke Center for Human Genetics, he was funded by the Duke Translational Medicine Institute and Glaucoma Research Foundation to study the effects of DNA copy number variants (CNV) in glaucoma. Dr. Liu is currently characterizing genetic risk variants identified through large scale genome-wide association studies (GWAS) using bioinformatics, molecular genetics, and animal models. Dr. Liu is also director of the CHG Molecular Genetics Core facility.

PhD, 2006, Molecular Genetics, University of Tenneessee, Knoxville, TN

Selected Publications


Liu Y, Liu W, Crooks K, Schmidt S, Allingham RR, Hauser MA. No evidence of association of heterozygous NTF4 Mutations in Patients with Primary Open-Angle Glaucoma. Am J Hum Genet. In press.

Liu W, Liu Y, Qin X, Schmidt S, Hauser MA, Allingham RR. AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. Mol Vis. 2010; 16:93-97.

Liu Y, Akafo S, Santiago-Turla C, Cohen CS, Larocure-Abramson KR, Qin X, Herndon LW, Challa P, Schmidt S, Hauser MA, Allingham RR. Optineurin coding variants in Ghanaian patients with primary open-Angle glaucoma. Mol Vis. 2008; 14:2367-2372.

Allingham RR, Liu Y, Rhee DJ. The genetics of primary open-Angle glaucoma: A review. Exp Eye Res. 2009. 88(4): 837-844.

Liu Y, Schmidt S, Qin X, Gibson J, Hutchins K, Santiago-Turla C, Wiggs JL, Budenz DL, Akafo S, Challa P, Herndon LW, Hauser MA, Allingham RR. Lack of Association between LOXL1 Variants and Primary Open-angle Glaucoma in Three Different Populations. Invest Ophthalmol Vis Sci. 2008. 49: 3465- 3468.

Challa P, Schmidt S, Liu Y, Qin X, Vann RR, Gonzalez P, Allingham RR, Hauser MA. Analysis of LOXL 1 polymorphisms in a United States population with pseudoexfoliation glaucoma. Mol Vis. 2008. 14: 146-149.

Liu Y, Schmidt S, Qin X, Gibson J, Munro D, Wiggs JL, Hauser MA, Allingham RR. No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations. Mol Vis. 2007. 13: 2137-2141.

Parkinson Disease
Gao X, Martin ER, Liu Y, Mayhew G, Vance JM, Scott WK. Genome-wide linkage screen in familial Parkinson disease identifies novel loci on chromosomes 3 and 18. Am J Hum Genet. 2009. 84:499-504.

Animal Models of Human Disease
Liu Y, Das S, Carpenter DA, Cain KT, Sundberg JP, Michaud EJ, Voy BH. Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R) in the hairless gene (Hr). Vet Pathol. 201 0. 47(1): 167-176.

Garvey SM, Liu Y, Miller SE, Hauser MA. Myotilin overexpression enhances myopathology in the LGMD 1A mouse model. Muscle Nerve. 2008. 37: 663-667.

Liu Y, Das S, Olszewski RE, Carpenter DA, Culiat CT, Sundberg JP, Soteropoulos P, Liu X, Doktycz MJ, Michaud EJ, Voy BH. The near naked hairless mutation disrupts hair formation but is not due to a mutation in the hairless gene. J Invest Dermatol. 2007. 127: 1605-1614.

Contact at:
Center for Human Genetics
DUMC Box 3445
Durham, NC 27710
Phone: 1-919-684-7090
Fax: 1-919-684-0918
E-mail: yutao.liu@duke.edu

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