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Research Informatics Resource


Informatics at a Glance

PEDIGENE®

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Clinical and Laboratory Informatics Core

Core Director: Elizabeth R. Hauser, PhD
Informatics Manager: Barbara Due

The Clinical and Laboratory Informatics Core at the Duke Center for Human Genetics has provided Duke faculty, staff, and collaborators with informatics solutions in support of human genetics and genomics research for over a decade. The Informatics Core is available to all Duke researchers and their collaborators, and in 2008, was approved as a School Medicine Shared Resource. We are committed to providing state-of-the art informatics solutions that integrate clinical, molecular and sample data with analysis tools quickly and efficiently on a research-computing network.

We perform the following essential functions for the Duke CHG and their collaborators:

  • Manage an extensive local area network of Windows-based PCs for office productivity applications and UNIX systems for scientific computing.
  • Maintain and extend the PEDIGENE® system: a secure, HIPAA-compliant, research database for storage of clinical, epidemiologic, and genetic data.
  • Provide applications for entering data into and extracting data from PEDIGENE®.
  • Administer Nautilus LIMS to facilitate tracking of samples, reagents, and laboratory results.
  • Develop user tools from the genetic epidemiology and statistical genetics group for data analysis.

The cornerstone of the Duke CHG informatics system is PEDIGENE®, a flexible integrated system for managing large databases containing clinical, pedigree, molecular, and DNA sample data. A CTSA-affiliated core resource, PEDIGENE® has been used to provide data storage, data description, and data analysis support for all studies conducted by CHG investigators and their collaborators. Getting Started with PEDIGENE®

In conjunction with PEDIGENE®, the CHG operates the Nautilus Laboratory Information Management system (LIMS). Nautilus, developed by Thermo Fisher Scientific, Inc., offers a secure, user-friendly way to track, collect, move, and store sample and laboratory data for the CHG's DNA Bank and Tissue Repository. Flow modules have been designed to manage requisition processing, storage location and sample availability, extraction, storage and allocation amounts, client billing and laboratory supply information. For those samples that are processed in the Molecular Genotyping Core, Nautilus is again used to track billing information, and molecular results are subsequently stored in PEDIGENE®.

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