THe EMK program implements two family-based association methods,
allele- and genotype- based association methods, that we developed
based on the framework of the allele-based method developed by Monks
and Kaplan (2000) for quantitative traits (Li et al. 2008). Our
version of allele-based EMK (allele-EMK) and genotype-based EMK (geno-EMK)
methods are applicable to any pedigree structure, for instance,
nuclear families with or without parental genotypes, and extended pedigrees.
Currently, EMK program is fit to bi-allelic markers (e.g. single nucleotide polymorphisms).
Li YW, Martin ER, Li YJ (2008) EMK: A Novel Program for Family-Based Allelic and Genotypic Association Tests on Quantitative Traits. Annals of Human
Genetics 72 (Pt 3): 388-396.
Monks SA and Kaplan NL (2000) Removing the sampling restrictions from
family-based tests of association for a quantitative-trait locus.
Am J Hum Genet 66:576-592
The EMK software is written in C++ and is available for the Solaris and Windows platforms. Please fill out the form below to download the EMK Program. Enter the following in the "Input Word" field: EMK_SOFTWARE
Please contact Yi-ju Li if you have any questions.