Combined Likelihood Ratio Test for Candidate Gene Studies, Version 1.0
The Combined Likelihood Ratio Test (Combined_LRT) is an
extension of the original likelihood ratio test (LRT) proposed by
Weinberg et al. (1999) to test child genotype risk, maternal genotype effects and
parent-of-origin (POO) effects. This program uses single locus genotype data
from case-parent triads to fit a log-linear model with genotype and imprinting
effects at a candidate gene. The model is fit to bi-allelic data
with possible missing genotype data for the mother or father, and
includes sibling genotypes. Likelihood ratio tests for parameter effects are
obtained from program output.
Reference: Rampersaud E, Morris RW, Weinberg CR, Speer MC, Martin ER. Power
calculations for likelihood ratio tests for offspring genotype risks,
maternal effects, and parent-of-origin (POO) effects in the presence of
missing parental genotypes when unaffected siblings are available. Genet Epidemiol. 2006 Nov 9
Please fill out the form below to download the LRT Program.
The zip file contains four files, two of which require SAS running on a Windows system.
Enter the following in the "Input Word" field: LRT_SOFTWARE