SIMLA is a SIMuLAtion program that generates data sets of families for use in Linkage and Association studies. It allows the user flexibility in specifying marker and disease placement, locus heterogeneity, disequilibrium between markers and between markers and disease loci. Output is in the form of a LINKAGE (Lathrop et al., Proc Natl Acad Sci USA 81, 1984) pedigree file and is easily utilized, either directly or with minimal reformatting, as input for various genetic analysis packages.
SIMLA_3.2 is a major upgrade to versions 2.3 and 3.0 that provides the ability to simulate two disease loci and two environmental covariates. Gene-gene and gene-environment interactions may also be simulated which jointly determine the disease risk of all pedigree members. Further enhancements include the simulation of X-linked markers and QTL effects with up to 12000 marker loci.
A description of the underlying simulation algorithm can be found in:
Schmidt MA, Hauser ER, Martin ER, Schmidt S. Extension of the SIMLA package for gener
ating pedigrees with complex inheritance patterns: Environmental covariates, gene-gene a
nd gene-environment interaction.Stat Appl Genet Mol Biol 4(1): article 15, 2005.
Please fill out the form below to download the SIMLA_3.2 program. This version is available for the Solaris, Linux and the Windows Operating Systems only. OSX
is available by request only. Enter the following in the "Input Word" field: SIMLA_SOFTWARE