SIMLAPLOT is a tool designed to help visualize the joint effect of genes and
continuous environmental covariates on complex human disease simulation
models (e.g. Schmidt et al. 2007). SIMLAPLOT takes as input the set of
genetic model parameters used to generate the data, including risk ratios
for genotypes (G), a normally distributed environmental covariate (E) and
their interaction (GXE), or the risk ratio for a continuous covariate that
is itself influenced by a quantitative trait locus (QTL) and thus follows a
mixture normal distribution. It is also possible to use SIMLAPLOT to plot
observed data distributions, if estimates of these parameters can be
provided.
Please fill out the form below to download the SIMLAPLOT manual and R function. Enter the following in the "Input Word field" SIMLAPLOT_SOFTWARE
